Treatment

Polynucleotides

A regenerative injectable derived from purified DNA fragments that improves skin quality, hydration and elasticity from within.

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Benefits

Benefits of Polynucleotides

01Improves skin quality, elasticity and firmness

02Boosts hydration from within

03Particularly suited to the delicate under-eye area

04Supports natural repair and renewal

05Improves tired, thin or crepey skin

06Natural, gradual results

Practical facts

At a glance

Treatment duration30 min

Result lastsSeveral months with maintenance

Sessions required2–3 sessions

DowntimeNone

DriveSame day

ShowerSame day

SportWait 24 hours

Sexual activityNo restriction

Testimonials

What our patients say

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★★★★★

“The consultation was clear, thoughtful, and never rushed. Very natural result, exactly as I wanted.”

Patient NameGoogle

★★★★★

“The whole team made the process feel straightforward, I really recommend them.”

Patient NameGoogle

★★★★★

“Thank you so much, I was a bit scared, but everything went well. I feel refreshed and younger.”

Patient NameGoogle

How it works

How does Polynucleotides work

The polynucleotide gel is injected into or just beneath the skin across the treatment area. Once in place it supports the activity of skin cells and fibroblasts, encouraging repair, better hydration and gradual improvement in elasticity and firmness. Because it works by stimulating your own skin over time, results build across a course of sessions rather than appearing instantly.

Polynucleotides support the skin's own repair machinery:

Cellular repair — provide building blocks that support skin cell renewal

Fibroblast stimulation — encourage the cells that produce collagen and elastin

Deep hydration — improve the skin's ability to hold moisture

Anti-inflammatory action — help calm and improve the skin's overall environment

Patient Journey

What to expect

Stage 01

Consultation

Every treatment begins with a consultation. Your practitioner assesses your skin quality and concerns, discusses whether polynucleotides or another treatment best suits your goals, reviews your medical history including any allergies to fish, and agrees a course before proceeding.

Stage 03

Treatment

After cleansing and applying numbing cream, the polynucleotide product is injected across the treatment area using a fine needle, with a series of small injections placed evenly. You may feel brief pinches and mild pressure. The appointment usually takes around thirty minutes. Small bumps at the injection points are normal at first and settle within hours to a day. Aftercare advice is provided before you leave.

Patient results

View Before & After Results

Explore real patient outcomes and see the considered results achieved across our treatments and procedures.

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Polynucleotides — before and after

Safety & suitability

Contraindications, risks and side effects

Contraindications

Pregnant or breastfeedingKnown allergy to fish or to the productActive infection or inflammation at the siteCertain autoimmune conditionsActive skin infection such as a cold sore in the area

Risks and side effects

Temporary swelling and rednessSmall bumps at the injection points that settle within hours to a dayBruisingTenderness in the treated areaRarely, infection or an allergic reaction

Price

Polynucleotides at Vale Clinic

Available atVale Clinic Manchester

Polynucleotides (single session)£300

Polynucleotides - Course of 3£800

Book nowor send us a message or send us a WhatsApp message

Practitioner

Who performs Polynucleotides

Dr Anne Nelson

Aesthetic DoctorMBBSGMC · 123456

Dr Nalson works predominantly with injectable treatments of the lower face, and takes a conservative, proportion-led approach to lip enhancement. She reviews every patient at two weeks before considering any adjustment.

LocationVale Clinic Manchester

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FAQs

Common questions

How many sessions will I need?

Usually a course of two to three sessions spaced a few weeks apart, followed by occasional maintenance.

How is this different from filler?

Filler adds volume, while polynucleotides improve the quality, hydration and elasticity of the skin itself. They can be used together.

When will I see results?

Improvement builds gradually over several weeks as the skin repairs, with the best results after completing the course.

Is it suitable under the eyes?

Yes, it is one of the most popular treatments for improving the quality of delicate, crepey under-eye skin.

Is there downtime?

Minimal, aside from small temporary bumps and possible minor bruising.

Polynucleotides

Benefits of Polynucleotides

At a glance

What our patients say

How does Polynucleotides work